Hypoxia-mediated radiation and chemo-sensitizing drugs

Selective PARP-1 Targeting for Designing Chemo/Radio Sensitizing Agents

Targeted drugs in concert with chemo: opposites

and therefore expected dominance of the manipulated unit. It is possible that the chimerism was transient and measurements were made too late, or that the fucosylated unit served to facilitate engraftment of the fucosylated and nonfucosylated HSPCs. This study represents an important advancement in the field ofUCB transplant. The strategy used is appealing because it is simple and could be perf...

Co-treatment by docetaxel and vinblastine breaks down P-glycoprotein mediated chemo-resistance

Objective(s): Chemoresistance remains the main causes of treatment failure and mortality in cancer patients. There is an urgent need to investigate novel approaches to improve current therapeutic modalities and increase cancer patients' survival. Induction of drug efflux due to overexpression of                  P-glycoproteins is considered as an important leading cause of multidrug resistance...

Regression of lung cancer by hypoxia-sensitizing ruthenium polypyridyl complexes.

The ruthenium (II) polypyridyl complexes (RPC), Δ-[(phen)2Ru(tatpp)]Cl2 (Δ-[3]Cl2) and ΔΔ-[(phen)2Ru(tatpp)Ru(phen)2]Cl4 (ΔΔ-[4]Cl4, are a new generation of metal-based antitumor agents. These RPCs bind DNA via intercalation of the tatpp ligand, which itself is redox-active and is easily reduced at biologically relevant potentials. We have previously shown that RPC 4(4+) cleaves DNA when reduce...

Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation.

We report a prototype approach to formulate gold nanoparticle-based X-ray absorbing agents through surface-engineering of a cisplatin pharmacophore with modified polyacrylate. The resulting agents exhibit both chemo-therapeutic potency to cancer cells and Auger-mediated secondary electron emission, showing great potential to improve the therapeutic efficacy of chemo-radiation.